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The current creation Hence also concerns a bacterial shipping and delivery auto, as described higher than, to be used in in vivo shipping and delivery of a nucleic acid of interest right into a specific receiver bacterial mobile, as described previously mentioned, wherein stated bacterial shipping auto comprises the vector of the creation.
claimed vector, bacterial supply car or truck or donor bacterial cell may be much more specially administered in the form of the pharmaceutical or cosmetic composition comprising explained vector, bacterial delivery car or donor bacterial mobile and also a pharmaceutically satisfactory provider.
This protein could be expressed from a distinct replicon (in trans) than the plasmid carrying the R6K origin of replication. In this case the replication from the R6K on plasmid is conditional over the expression on the pir gene in trans. When shipped to a germs of fascination, the plasmid won't replicate unless the pir gene is existing and expressed.
In a certain embodiment, the 開始賭場之旅 donor bacterial cell on the creation comprises the above-outlined helper phage.
As applied herein, the time period «supply motor vehicle» refers to any vehicle which allows the transfer of the vector or payload right into a bacterium.
As used herein, the term “packaged phagemid” refers to a phagemid and that is encapsidated inside of a bacteriophage scaffold, bacterial virus particle or capsid. notably, it refers into a bacteriophage scaffold, bacterial virus particle or capsid devoid of a bacteriophage genome. The packaged phagemid could be made with a helper phage strategy, famous through the guy experienced during the artwork. The helper phage comprises many of the genes coding for your structural and functional proteins which can be indispensable for the phagemid in accordance with the invention to get encapsidated.
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in a few embodiments, the pharmaceutical or veterinary or cosmetic compositions absolutely are a powder that could be provided into a tablet or simply a suppository.
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whereby stated vector even more comprises a conditional origin of replication that is inactive while in the specific receiver bacterial mobile but is Lively within a donor bacterial cell, and stated vector is devoid of antibiotic resistance marker,
As a Manage for unspecific killing, packaged phagemids were also transduced into your pressure s11983, that is a spinoff of the O157 H10dstx strain lacking the lacZ gene.
In a certain embodiment, the influence of reported vector induces or improves a synergy with the influence of the extra Lively component. In a far more individual embodiment, explained vector enables reported probiotic to engraft into mentioned host organism.
In a particular embodiment, mentioned given outcome is creating the receiver bacterial mobile produce a molecule of interest, specifically a number modulatory molecule.
本发明涉及用于调节宿主微生物组的感兴趣的核酸，涉及编码所述核酸的载体以及涉及用于通过递送所述感兴趣的核酸来调节宿主微生物组的方法。